Waller-Bridge won the 2017 BAFTA TV Award for Best Female Performance in a Comedy, for her role in Fleabag, a television series which she developed, wrote and starred in, which is based upon her stage play of the same name. In 2019, she won three Emmy awards for the show's second and final season, for Outstanding Writing In A Comedy Series, Outstanding Lead Actress In A Comedy Series, and Outstanding Comedy Series.
Waller-Bridge was also the showrunner, head writer, and executive producer of the first season of Killing Eve, a BBC America television series based upon the Codename Villanelle novellas of Luke Jennings.
She co-wrote the Daniel Craig-led James Bond film No Time to Die and appears alongside Harrison Ford in the Indiana Jones film Indiana Jones and the Dial of Destiny in 2023.