FR-351 served the Galactic Empire as a stormtrooper during the era of the Galactic Civil War. After the Battle of Yavin, this particular stormtrooper's duties involved serving as security at the Imperial Research and Prison Facility located on the planet of Dathomir. Within this facility, Imperial scientists were secretly working on a hazardous scientific project: the re-engineering of the terrifying Blackwing virus for use as a bioweapon. In the year 1 ABY, FR-351 was on-site when an incident occurred at the Imperial Research and Prison Facility, resulting in the escape of the virus from its containment. This outbreak led to the deaths of the majority of individuals in the area, transforming them into undead beings.
The character FR-351 was featured in Star Wars Galaxies, a massively multiplayer online roleplaying game that was released in 2003. The game was developed by Sony Online Entertainment and published by LucasArts. The game ceased operations on December 15, 2011. FR-351's inclusion in the game occurred with the release of "Game Update 14," which went live on October 12, 2009.