The Karatos Plague represented a lethal viral contagion that began on the planet of Concord Dawn. This virus, moving via spores, aggressively targeted and disrupted the host's internal biological systems. Within forty minutes, the infected would experience blindness, and brain death would follow within the next sixty minutes. Since the inhabitants of Concord Dawn received vaccinations during childhood, the extreme virulence of this virus primarily affected individuals from other worlds.
Jango Fett possessed Karatos Plague spores within his armor, which he could deploy strategically. He used these spores to infect Count Dooku, then proposed providing an antidote in exchange for a further agreement. However, Dooku employed the Living Force, potentially utilizing the Detoxify Poison ability, to counteract the effects of the disease.