The Prolifera system existed within the Corosi sector, which itself was situated in the New Territories region of the Outer Rim Territories.
The Prolifera system was the origin point of the Proliferan species, a sentient race, and lent its name to the Proliferan Empire established by them.
The 2009 publication The Essential Atlas, authored by Daniel Wallace together with Jason Fry, first featured the Prolifera system, designating its location as grid square N-6.