Tyris Santorini was a being who specialized in managing creatures. She existed during the era of the Galactic Civil War. After the Battle of Yavin, Santorini served as part of the Galactic Empire's support personnel. She was stationed at the Imperial Research and Prison Facility located on the world of Dathomir. Within this facility, scientists were secretly engaged in perilous research for the Empire, with the goal of transforming the terrible Blackwing virus into a biological weapon. Santorini's duties were carried out in the holding sections of level 3 within the facility. In 1 ABY, Tyris Santorini was present when an incident occurred at the Imperial Research and Prison Facility, resulting in the escape of the virus from its containment. The majority of individuals within the affected zone were killed by the virus, transforming them into undead beings.
The character Tyris Santorini was referenced in the 2003 video game Star Wars Galaxies. This game was a massively multiplayer online roleplaying game developed by Sony Online Entertainment and published by LucasArts. The game was eventually shut down on December 15, 2011. The mention of Tyris Santorini was incorporated into the game through "Game Update 14," which was released on October 12, 2009.