The Adrenal Research Base served as a scientific research installation. It was operated by the Republic Military on the world of Quesh, with the purpose of researching the replication of venenit queshaaga, otherwise known as Quesh venom. Approximately in 3642 BBY, the Sith Empire launched an assault on the base, which required the Jedi Knight referred to as the Hero of Tython to mount a defense, aided by the 86th Infantry and the Jedi Padawan named Sajar.