The Anodyne Two served as a starship in the conflict known as the war between the First Order and the Resistance. Its designation echoed that of the Anodyne, a Nebulon-C escort frigate belonging to the Resistance that met its end at the hands of the First Order during an attack targeting the Resistance's fleet. In response to General Lando Calrissian's plea for assistance during the Resistance's battle against the Sith Eternal forces in the skies above the planet Exegol, the Anodyne Two became part of a fleet assembled to aid them.