The Guild of Compassionate Merchants existed as an organization within the galaxy throughout the High Republic Era. The Twi'lek named Sestin Blin was employed by the Guild on Wroona until approximately 244 BBY. After embezzling funds from the Guild for a number of years, Sestin was discovered. Sestin fled, and the Guild subsequently employed an enforcer to pursue her. After she killed the enforcer, Sestin was taken into custody for committing murder.
The audio drama The High Republic: Tempest Runner, which was released in 2021 and authored by Cavan Scott with a complete voice acting ensemble, included a reference to the Guild of Compassionate Merchants.