The itching plague presented a rather unusual challenge during the Vongforming process of Yuuzhan'tar, after the Yuuzhan Vong had seized control of Coruscant.
This plague, a fungus disseminated by the World Brain, induced intense and unremitting itching. Despite the Yuuzhan Vong's supposed resilience, several prominent members of the Elite were surprisingly vulnerable to the stress caused by the fungi. Furthermore, the plague's emergence was ill-timed, coinciding with the arrival of Supreme Overlord Shimrra on Yuuzhan'tar. Ultimately, Master Shaper Nen Yim succeeded in creating an anti-fungal balm, although its effectiveness was limited to direct contact, leaving individuals susceptible to re-infection. As of 29 ABY, a couple of years after its initial outbreak, the plague continued to persist.