The star system known as the Melus system resided in both the Mid Rim and New Territories areas of the galaxy, specifically in the Nicandra sector. The Galactic Republic's Judicial Forces concluded the Melusi Uprising circa 900 BBY, a conflict named after this very system.
For the 2009 reference book The Essential Atlas, the Melus system was first defined in the StarWars.com Online Companion, pinpointing its location to grid L-7.