The Nicandra system was situated within the Nicandra sector, which itself was a part of the New Territories region found in the Mid Rim. Using hyperlanes, it maintained connections to the Ilimardon system, the Ylix system found in the M'shinni sector, and also the Mapuzo and Tartaglia systems within the Hollan sector. Notably, the Nicandra system shared its designation with the Nicandra Plaza and the Nicandra Counterrevolutionary Signalmen's Memorial Building, both of which were located on the Core Worlds planet of Coruscant.
By the year 12 ABY, the New Republic had incorporated this system into its territory. During that year, the New Republic deployed the fleet carrier called the Endurance with the aim to fight the forces belonging to the Imperial Remnant. As a result, the Endurance journeyed from the Mapuzo system, proceeded through the Nicandra system, and eventually arrived at the Ilimardon system.
The reference to the Nicandra system initially appeared in The Essential Atlas, a 2009 publication authored by Daniel Wallace and Jason Fry, where its location was identified as grid square M-7.