Prince Sereno held the position of supreme commander for the Tofs. He spearheaded the Tof's galactic assault, which occurred in 4 ABY. The impetus for the Tof campaign was their relentless pursuit of the Nagai, a race they had previously subjugated and held in bondage. Following an initial clash at Trenwyth and the establishment of an operational hub on Saijo, the Tofs launched an invasion of Zeltros.
Having been pushed back at Zeltros by a collaborative defense, Sereno forged an alliance with Dark Lady of the Sith Lumiya with the goal of overcoming the Rebel Alliance. During the Battle of Saijo, Sereno remained within the confines of his royal court while his military engaged the Alliance forces in brutal trench warfare across the planet's terrain.
While Sereno was in conference with Lumiya, a specialized Alliance strike team managed to infiltrate Sereno's palace on Saijo. During a brief, isolated exchange of gunfire, Sereno succumbed to fear and shouted orders for his personal guard to defend him. Regrettably for the Tof commander, the Jedi Luke Skywalker, wielding two sabers, successfully apprehended him. Skywalker compelled Sereno to issue a call for surrender, effectively concluding the Nagai–Tof War.