The Battle of Loedorvia occurred as a component of Operation Durge's Lance, which was a Separatist attack directed at the Core Worlds. During this conflict, General Grievous, who thought that instilling fear in non-combatants was the heart of warfare, unleashed the Brainrot Plague. The Weemell sector was entirely infected by the plague, which resulted in the deaths of all Clone armies and almost every Human residing there.
The Weemell sector was rendered temporarily unlivable because of the plague. The deployment of the Brainrot Plague, alongside events such as the bombardment of Humbarine, deeply disturbed the inhabitants of the Core Worlds. The Separatist faction also experienced internal disagreements regarding the employment of bioweapons. Dooku was concerned that utilizing such weapons could bolster Republic propaganda, whereas figures such as Nute Gunray and Lott Dod viewed it as offensive to Neimoidians, given their frequent vulnerability to plagues and illnesses.