Painkillers functioned as a kind of analgesic, designed to alleviate or completely remove pain.
Once, following the start of her menstrual cycle, Queen Padmé Amidala remained in bed for a number of hours, anticipating the effects of painkillers.
A painkiller known as pain-relieving gas was given to Imperial medics and administered on the planet Mimban within the Expansion Region during the Mimban Campaign in 10 BBY to address a concussion sustained by Corporal Chakobi Sanwright.