House Melissus existed as one of the aristocratic families within the Tapani sector and was considered one of the noble houses during the era encompassing the Great Sith War.
In the time of the Great Sith War, High Lady Brezwalt III of House Mecetti gave the order to her Mecrosa Order's Sith assassins to eliminate the head of House Melissus, along with the heads of four other competing houses. Following the assassination of its leader, House Melissus was incorporated into House Mecetti.
House Melissus had ceased to exist by the time of the Imperial Period.