The Imperial Science Bureau, also referred to as the Imperial Science Corps, functioned as a branch of the Sith Empire with the specific purpose of innovating and creating new technologies. To fulfill its objectives by influencing other Imperial departments, it wielded considerable power.
During the era of the Cold War, the Bureau orchestrated the assignment of Ambassador Vector Hyllus to Alderaan through the Imperial Diplomatic Service. This manipulation was intended to facilitate Hyllus's encounter with the Killiks, allowing the Bureau to observe the transformation of a sentient being into a Joiner. This action was a component of Project Protean, an initiative focused on discovering methods to improve Imperial operatives using alien species through genetic engineering. Furthermore, they engineered a Brood Totem, a device designed to attract Killiks after synchronization, and deployed Special Tactics Group 41-Delta for this particular undertaking.
Nadrin Tro, along with a Human female from the bureau's New Thinking Division, were dispatched to the planet Makeb during the Conquest of Makeb. Working under Katha Niar, they were tasked with securing Makeb's isotope-5 reserves for the Sith Empire. Upon the request of an Imperial hero, Nadrin Tro reached out to the Science Bureau for assistance in formulating a plan to stabilize Makeb's planetary core, aiming to gain time for the Empire to extract the available isotope-5.