During the Imperial Era, orange single-use hazmat suits with darkened faceplates were used on the planet Cynda, its moon Gorse, and the Imperial space station Calcoraan Depot. Starships used by Moonglow Polychemical, including the company's explosives haulers, had a stash of the suits as standard-issue, as part of company chief Lal Grallik's safety precautions. The suits were necessary when handling the volatile baradium bisulfate, as the so-called "Nasty Baby" was stored in canisters with a psychoactive coolant, which could cause people to hallucinate if inhaled. While infiltrating Calcoraan Depot in search of information on Count Denetrius Vidian's plans, Kanan Jarrus, Hera Syndulla, Zaluna Myder and Skelly took advantage of the suits' use as disguises amongst a horde of identically-dressed workers, as Jarrus and Syndulla had had run-ins with Imperial personnel and Skelly was wanted for bombing several shuttles.
Hazmat suits first canonically appeared in the Star Wars: The Clone Wars first season episode "Blue Shadow Virus".