Horn Ambigene, celebrated as a native of the Tydane system, hailed from there. Subsequently, during the Republic Era, he took on the responsibility of commanding an anti-Galactic Republic militia for several decades. However, with the arrival of the Clone Wars, Ambigene transitioned to supporting the Confederacy of Independent Systems in their conflict against the Republic, serving as a general within their ground forces. During his commitment to the Separatist cause, Count Dooku, the Head of State of the Confederacy, positioned Ambigene on the planet Pzandias located within the Bryx sector. In that location, he was assigned the role of Commander of Organic Training, with the task of instructing fellow Separatists in the methods of defending their respective homeworlds against the Republic.
The current Star Wars canon saw the introduction of Horn Ambigene within Rise of the Separatists. This book is a 2019 addition to the Star Wars Roleplaying series by Fantasy Flight Games. Within the Star Wars Legends timeline, Horn Ambigene made his debut in The Essential Guide to Warfare, a reference work from 2012 penned by Jason Fry and Paul R. Urquhart.