The Serenno blockade represents a conflict that transpired in the orbit of the planet Serenno at some juncture between 22 BBY and 19 BBY, within the time frame of the Clone Wars. This war saw the Galactic Republic battling against the Confederacy of Independent Systems. Throughout the blockade, the Confederacy employed multiple Dual Hemisphere-Omni Support Vessels to safeguard the planet, which served as the homeworld for Count Dooku, their governmental leader.
The Serenno blockade was referenced within the seventieth issue of the Star Wars: Build the Millennium Falcon magazine by De Agostini, which was released circa May 4, 2016. A typographical error appeared in the issue, rendering the blockade's name as "blockade of Serreno."