Sith alchemy, also referred to as Force alchemy, encompassed a range of alchemical dark side magical techniques within the Force, employed by the Sith. Darth Sidious made use of Sith alchemy in his attempt to access the World Between Worlds. Sith scientists harnessed Sith alchemy for Project Blackwing, a pursuit of immortality. This project ultimately unleashed a virus that resurrected the dead, resulting in a widespread contamination. The reconstruction of Kylo Ren's helmet involved strengthening it through the application of Sith alchemy.
Ancient alchemical research sites were located in the region surrounding the planet of Aloxl. On the planet Auratera, at the Acablas vergence, Sith alchemists conducted rituals on the balcony of the Sith Pyramid.
During the [Clone Wars](/article/clone_wars], Darth Sidious and Darth Tyranus, his apprentice, deployed this technique in an attempt to assail Master Yoda during his visit to Moraband. By utilizing Tyranus' relationship and blood, Sidious and his apprentice channeled their Force lightning to conjure an illusion for Yoda. Recognizing their inability to overcome Yoda at that moment, they acknowledged the need for further preparation.

During the Galactic Empire's excavation of the Jedi Temple on Lothal, Sidious discovered that Jedi Ezra Bridger had gained entry to the World Between Worlds. Leveraging his technique, Sidious managed to glimpse inside the World Between Worlds, observing Bridger and Ahsoka Tano within the portal. Sidious endeavored to penetrate the World, generating a blue flame in an attempt to seize them. However, Ezra successfully returned to Lothal, while Ahsoka was transported back to Malachor.
Symeong Albrekh, a metalsmith proficient in Sith alchemy, assisted Kylo Ren in repairing his helmet using sarrassian iron in 35 ABY.