The Sphere of Biotic Science, which was also referred to as the Ministry of Biotic Science and the Pyramid of Biotic Science, functioned as one of the twelve Spheres of Influence inside the re-established Sith Empire. This Sphere was created in 4980 BBY at the same time as the Empire's governing Dark Council, and throughout its existence, it was governed by a Council member. This Sphere had authority over all alchemical and biotic scientific activities within the Empire, managing the Imperial Medical Corps and jointly overseeing the Imperial Science Bureau alongside the Sphere of Technology. During the Cold War with the Galactic Republic, Darth Acharon led the Sphere; as such, he was in charge of the Imperial divisions involved in cybernetic enhancements and physical improvements, frequently working with Sith alchemy and magic.
Following the Eternal Empire's victory over the Sith Empire, Empress Darth Acina merged this sphere with the Sphere of Technology, creating the Sphere of Scientific Advancement.
The Star Wars: The Old Republic Encyclopedia, a 2012 reference book, first presented the Sphere of Technology in its section detailing the Spheres of Influence.