When Galen was taken by the Galactic Empire to work on the Death Star project by the Imperial Military Department of Advanced Weapons Research Director Orson Callan Krennic, Lyra was killed and Jyn went into hiding with the Partisans' leader Saw Gerrera. Ultimately, Jyn sacrificed her life at Scarif when she stole the Death Star plans to give them to the Alliance to Restore the Republic before being killed by the Death Star's superweapon. As Jyn never had descendants, the family line ended with her.
In early versions of the Rogue One story, the matriarch of the family was a surviving Jedi, and there was additionally a younger brother for Jyn to look after.
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