The Metharian Nebula Territories constituted an area situated within the Outer Rim Territories. This area derived its designation from the Metharian Nebula, a nebula that resided within the Tantra sector.
The Rimma Trade Route cut through the Metharian Nebula Territories. Additionally, the hyperlanes referred to as the Coyn Route and the Elrood-Derilyn Trade Route were located here.
A remote corner of the Metharian Nebula Territories housed the Elrood sector. The Tantra system of the Tantra sector was also found within this region.
In 22 BBY, during the time of the Separatist Crisis, Count Dooku's presence in the Metharian Nebula Territories incited a series of secessions along the Rimward section of the Rimma Trade Route. Consequently, the sectors of Elrood, Danjar, Tantra, and Sluis aligned themselves with the Confederacy of Independent Systems, which rendered the entire Rimward segment of the Rimma Trade Route inaccessible to the Galactic Republic.
During the era of the Galactic Civil War, the Galactic Empire exerted control over the Metharian Nebula Territories.