Following the Second Battle of Geonosis, the Grand Army of the Republic's Tango Company was assigned to escort TB-73—a Pelta-class Medical Frigate under the command of Jedi Commanders Ahsoka Tano and Barriss Offee— to the Ord Cestus medical station. However, clone trooper Scythe was infected with a Geonosian brain worm and secretly brought a batch of eggs aboard the starship in his backpack. Onboard the medical frigate, he caused the infection to spread to other clones, including Edge, Havoc, Ox, Pulsar, and Lieutenant Trap. The infected clones even killed their own brothers, executing the pilots as they took over the bridge. Burrowing within the brains of the infected soldiers, the worms controlled their hosts' actions and forced them to attack the Jedi.
As the worm infestation spread to the rest of the ship's crew, infecting Offee in the process, Tano attempted to regain control of the vessel before its arrival at Ord Cestus. Ultimately, she prevented the infection from spreading to the medical station by deactivating the frigate's climate control, thereby causing the worms to lose control of their hosts as they froze to death.
Green Aurebesh graffiti next to the exit of the latrine in the 79's cantina on Coruscant said "TANGO CO".
The clones of Tango Company wore Phase I clone trooper armor, with many troopers customizing their armor with blue markings. Many of the clones also had the Tango Company logo adorned on their armor. Several troopers, including Scythe, had backpacks to carry extra equipment.